Vasospasm Prevention with Statins — Quick Review

Antonio Luo, PHARMD/MBA Candidate has graciously prepared a fantastic review on vasospasm pervention with statins. The following is a summary and the actual document is above.

High-Dose Simvastatin Is Effective in Preventing Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study in Korean Patients

Conclusion: This study showed that preventive 80 mg simvastatin is an effective treatment for cerebral vasospasm after aneurysmal SAH in Korean patients, but does not necessarily improve the clinical outcomes of the patients.

High-dose simvastatin for aneurysmal subarachnoid hemorrhage: multicenter randomized controlled double-blinded clinical trial.

High-dose simvastatin treatment should not be prescribed routinely for aneurysmal subarachnoid hemorrhage.

Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): a multicentre randomised phase 3 trial

The STASH trial did not detect any benefit in the use of simvastatin for long-term or short-term outcome in patients with aneurysmal subarachnoid haemorrhage. Despite demonstrating no safety concerns, we conclude that patients with subarachnoid haemorrhage should not be treated routinely with simvastatin during the acute stages.

So, what do you think?


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